Transgenic plants as medicine production systems

Transgenic plants as vaccine production systems.

Transgenic plants that express foreign proteins with industrial or pharmaceutical value represent an economical alternative to fermentation-based production systems. Specific vaccines have been produced in plants as a result of the transient or stable expression of foreign genes. It has recently been shown that genes encoding antigens of bacterial and viral pathogens can be expressed in plants ...

Antibody production in transgenic plants.

Introduction In recent years, methods have been developed for the expression of immunoglobulin-encoding genes in a wide range of heterologous organisms, including non-lymphoid mammalian cells, insect cells, yeast, bacteria and plants. The isolation of antibodyencoding genes from hybridoma cells and their expression in these heterologous hosts has led to a revolution in monoclonal antibody techn...

Transgenic plants as bioreactors

Recent advances in molecular and cellular biology have led to the development of technology to engineer plants that are capable of producing a wide variety of products. These include products for pharmaceutical applications, like vaccine antigens, antibodies, antibody-derived fragments and other therapeutic proteins. It is possible to alter endogenous metabolic pathways to obtain new products, ...

Transgenic Plants as Gene-Discovery Tools

Mutation study is an important strategy to dissect gene functions. Classical chemical or irradiation mutagenesis is one of the most powerful screen approaches to uncover genes involved in certain genetic pathways. However, the tedious works to hunt down the gene corresponding to a mutant allele by map-base cloning make an intrinsic limitation of this approach. Loss-of-function mutations resulti...

Medicinal Plants as Immunosuppressive Agents in Traditional Iranian Medicine